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To overcome these issues, we applied a Standard Addition Method (SAM) 52 to mouse liver samples, in which the tissue samples were derivatised with IAM-TPP to trap any GSS as GSS-CAM-TPP, while also being spiked with a concentration range of GSS-CAM-TPP followed by quantification of total GSS-CAM-TPP

Two classes of newer anti-hyperglycemic agents can reduce CV risk and events in patients with T2D, namely glucagon-like peptide-1 receptor agonists (GLP-1RA) and sodium-glucose cotransporter-2 (SGLT-2) inhibitors

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Human studies in this area are limited by small sample size and often nonrandomized character

But they are incredibly expensive and their long-term risks are still unknown